Targeting the Root Cause
of Brain Disease
Founded in 2018, GoodCap is focused on neuroinflammation as a shared driver of psychiatric and neurodegenerative disease. Our approach isn’t to manage symptoms. It’s to disrupt the inflammatory and degenerative processes underneath them, across a platform designed to extend from PTSD into depression, anxiety, Parkinson’s, and Alzheimer’s.
One Biological Target, Multiple Diseases
Neuroinflammation and impaired neural repair are recurring biological features across a large and growing set of central nervous system (CNS) disorders:
332M
Depression
~ 1 in 25 people
worldwide
56.9M
Alzheimer’s
& Dementias
~ 1 in 85 people
aged ≥60
37.9M
TBI
~ 1 in 8 people
over lifetime
11.8M
Parkinson’s
~1 in 100 people
aged ≥60
Current Development Focus
~ 1 in 67 people
over lifetime
118M
PTSD
98.3M
Stroke
~ 1 in 4 people
over lifetime
Population estimates are global; PTSD shown as ~12-month prevalence. Disease populations overlap and should not be summed.
Sourcing: WHO 2021, Kessler et al. BMC Psychiatry 2023, GBD 2021
Why PTSD First
PTSD has seen only two FDA-approved treatments in over two decades. Minimal competitive density and comparatively efficient trial recruitment give GoodCap a faster, lower-risk route to its next pivotal readout and a foothold into the broader neuroinflammation platform.
The Origin
Co-founders Darryl Hudson, PhD and Irie Selkirk spent a decade working closely with military veterans and saw firsthand how poorly current treatments served them. Frontline SSRIs leave roughly two-thirds of PTSD patients without remission. This reflection led to the belief that a combination drug of triptamines and anti-inflammatory molecules would better treat PTSD’s underlying biology by getting to the root cause, and be more effective than a single serotonin-reuptake mechanism. That observation shaped the multi-mechanism approach GoodCap is developing today.
Clinical Path Forward
GoodCap has aligned a planned Phase 1a/1b program (safety and tolerability, initial efficacy signal, active-duty population) with U.S. military clinical research investigators, anchored at a leading medical and research institution.
